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Monocyte levels are linked to length of in-hospital stay in allergic rhinitis patients, with white blood cells acting as a mediator.
In a comprehensive analysis of real-world hospital data, researchers have found that elevated monocyte levels are closely associated with longer hospital stays in patients with allergic rhinitis (AR), with white blood cell (WBC) count acting as a potential mediator. The findings, drawn from the widely used MIMIC-IV database, suggest that common blood biomarkers could play a pivotal role in patient management and discharge planning.
The retrospective study, which included 937 hospitalized patients diagnosed with AR, sought to uncover clinical and laboratory factors linked with the length of in-hospital stay (LOS). Researchers identified patients with AR and relevant data from the MIMIC-IV database. Through correlation analysis and linear regression, the factors affecting LOS were determined. The most influential variables were ranked in terms of their significance. Finally, mediation analysis was employed to investigate potential mediating factors contributing to LOS.
Out of the initial variables analyzed, 10 were prominently correlated with LOS. Further regression analysis refined this list, identifying 6 key independent predictors:
1. Monocyte count
2. Albumin level
3. WBC count
4. Red blood cell (RBC) count
5. Red cell distribution width
6. Total calcium
After adjusting for comorbidities, monocyte count, WBC, RBC, albumin, total calcium, and Charlson Comorbidity Index remained statistically significant (all P < 0.05). Among these, monocyte count emerged as the most influential variable, as shown by permutation importance analysis, a machine learning technique that quantifies the impact of each variable on the outcome. Importantly, mediation analysis revealed that WBC count partially mediated the connection between monocyte count and LOS, indicating that systemic immune activity may play a causal role in determining hospital recovery duration for AR patients.
This study offers novel insight into how immune-related blood markers, particularly monocyte levels, can help forecast hospital stay duration in AR sufferers. The mediating role of WBC count further highlights the complex interplay between immune function and clinical outcomes. Thus, healthcare providers can tailor AR care strategies based on monocyte levels to support key clinical decisions and reduce hospital stays.
BMC Anesthesiology
Correlation between monocyte and length of in-hospital stay in patients with allergic rhinitis: data from the MIMIC-IV database
Die Fang et al.
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