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Glutathione shows promise in managing fatty liver disease by reducing liver fat accumulation, improving enzyme levels, and supporting detoxification, with greater benefits observed when combined with a healthy lifestyle.
Fatty liver disease develops when fat accumulation surpasses 5% of the liver’s total weight. It is categorized into alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD). If unaddressed, it can progress to liver cirrhosis. Antioxidants like glutathione, which is naturally produced by the body and concentrated in the liver, may help mitigate the condition.
This systematic review published in “The Indonesian Journal of General Medicine” examined the role of glutathione as an adjunct intervention for fatty liver disease. Pertinent randomized controlled trials were retrieved from Google Scholar and PubMed, identifying 1,141 cases of fatty liver. From these, two studies were selected for further analysis, both involving the effects of glutathione supplementation.
The two selected studies included a total of 208 patients, divided into intervention and control groups. The intervention group, which received glutathione supplementation for at least three months, showed noticeable improvements in liver health. Furthermore, there were reductions in controlled attenuation parameter (CAP), alanine aminotransferase (ALT), and intima-media thickness (IMT) values, indicating improved liver function and reduced fat accumulation.
The therapeutic benefits of glutathione were enhanced when combined with a medically healthy diet and lifestyle improvements, accelerating the recovery process. The findings suggest that glutathione acts as a hepatoprotector, helping to slow the progression of NAFLD and improve overall liver health.
The Indonesian Journal of General Medicine
Use Of Glutathione As An Additional Supplement For The Treatment Of Fatty Liver Disease : A Systematic Review
Pretty Grace Zalukhu et al.
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