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DASH diet may benefit certain people based on their genetic makeup (particularly those with TT genotype of rs1501299 and AA genotype of rs6450176). For G allele carriers of rs6450176, the diet might not offer the same benefits in reducing central obesity.
A cross-sectional study of 387 adults examined how genotypes of rs1501299 and rs6450176 single nucleotide polymorphism (SNPs) interact with the dietary approaches to stop hypertension (DASH) diet in relation to cardiometabolic risk factors. The participants, aged 20–70 years, were selected from the Yazd Health Study, a population-based cohort of nearly 10,000 adults. Researchers used the restriction fragment length polymorphism method to determine genotypes.
The study found that the effects of high adherence to the DASH diet on blood pressure and obesity measures varied by genotype. For those with the TT genotype of rs1501299, adherence to the DASH diet was linked to a reduction in both systolic and diastolic blood pressure (P-interaction = 0.051 and 0.014, respectively). However, for G allele carriers of this SNP, no such association was witnessed. Additionally, among those with the AA genotype of rs6450176, adherence to this diet was linked to lower systolic blood pressure (P-interaction = 0.012), waist-to-hip ratio (P-interaction = 0.026), and waist-to-height ratio (P-interaction = 0.040).
However, in G allele carriers, the mean values for these measures were higher in those with high compliance to the DASH diet. These findings indicate that the DASH diet may be linked with lower blood pressure and central obesity indices in those having TT genotype of rs1501299 and the AA genotype of rs6450176, respectively, while it may correlate with higher waist-to-hip ratio and waist-to-height ratio in G allele carriers of rs6450176.
Thus, the benefits of the DASH diet on blood pressure and obesity appear to be genotype-dependent, with some individuals experiencing more favorable outcomes based on their genetic makeup. These findings highlight the role of personalized nutrition in monitoring cardiovascular and metabolic health.
Scientific Reports
Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults
Mehdi Mollahosseini et al.
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