Clinical Research

Key Take-Away:

Radiofrequency thermocoagulation connected with anhydrous ethanol (AE) chemical blockade of the Multi-segmental Lumbar Sympathetic Ganglia was safe and effective. Nevertheless, the details underlying analgesic mechanisms still need to be investigated.  

As the quality of life is improving, the incidence of diabetes is increasing. Epidemiologists have suggested that the global prevalence of diabetes will reach 552 million by 2030. The rise in the incidence of diabetes leads to an increase in the rate of its complications.

Ding et al. Journal of Pain Research 2018:11 1375–1382
23min read    
Key Take-Away:

Greater quadriceps and hamstrings muscle strength was associated with less pain, less difficulty completing activities of daily living, and better mobility. These relationships should be evaluated longitudinally.

Knee osteoarthritis (OA) is a principal cause of functional disability in older adults, which results in difficulties in performing daily activities. To perform the daily functional tasks, an individual requires sufficient lower extremity muscle strength. It is reported that individuals with symptomatic knee osteoarthritis have deficits in quadriceps and hamstrings strength. As muscle strength is modifiable, understanding the relationships between the strength of quadriceps and hamstrings could help to determine effective treatment targets.

BMC Musculoskeletal Disorders
28min read    
Key Take-Away:

This study demonstrated that TIVA is more significant than SEVO in reducing the postoperative pain and incidence of ED in children undergoing dental surgery.

Rapid awakening after the use of anaesthetics has been proposed to generate emergence delirium (ED), which is an abnormal mental state that develops during the shift from unconsciousness to complete wakefulness. The prevalence of ED largely depends on various factors such as age, anaesthetic technique, surgical procedure, and administration of adjunct medication. The incidence of ED in pediatric anaesthesia is highest in children aged between 2-6 years.

Journal of Pain Research 2018:11 1289–1295
20min read    
Key Take-Away:

The LIA technique found to be a safe and effective treatment option for early functional recovery and pain control in TKA. The method showed significant advantages in terms of mobilization and muscle strength in the early postoperative period, whereas pain relief was almost similar in all study groups.

Nowadays, postoperative pain is still one of the most critical issues for clinicians. Treatment of postoperative pain after total knee arthroplasty (TKA) is even more challenging. To achieve better results, physicians should pay attention to the early mobilization, good functional outcome, optimal and enhanced recovery. Therefore, the primary goals are to reduce pain and immobilization and to minimize opioid dependency and their adverse events.

BMC Musculoskeletal Disorders
22min read    
Key Take-Away:

The present study has indicated the use of 10 or 15 μg of intrathecal fentanyl with 10 mg of bupivacaine in patients undergoing a cesarean section. The combination of 10 or 15 μg of intrathecal fentanyl with 10 mg of bupivacaine can be helpful in providing adequate surgical anaesthesia and analgesia with a lower incidence of side effects. 

Bupivacaine is the frequently used anaesthetics for the subarachnoid block in parturients undergoing the cesarean section. It is noticed that intrathecal bupivacaine alone is inadequate to provide entire anaesthesia. Therefore to improve the duration and quality of subarachnoid block, surgeons commonly add opioids such as fentanyl.

It is reported that intrathecal fentanyl is associated with the number of side effects such as pruritus, nausea/vomiting, and respiratory depression. The appropriate and safe dose of fentanyl is still unclear.

J Anaesthesiol Clin Pharmacol 2018;34:221-6
19min read