Abstracts

Key Take-Away:

As per the experts of the Consensus Meeting Group, the Nimesulide, in particular, is suitable for the treatment of different types of acute inflammatory pain. Labelled use of Nimesulide found to have good tolerability and similar safety profile to other NSAIDs. With the incidence of liver reactions 0.1 per 100,000 treated patients, the Nimesulide could be considered a valuable alternative to coxibs as it has comparable efficacy and lower cardiovascular risks.

Introduction:

Pain is a major cause of primary care consultations; acute pain can be considered as a warning signal of disease to the body. If the pain is not resolved in the expected healing period, it can lead to chronic pain. This study aimed to provide the latest insights from studies and case reports on the pathophysiology and treatment of acute pain with emphasis on Nimesulide indicated for the treatment of acute pain and primary dysmenorrhea.
This article compiles the outcomes of the International Consensus Meeting, held in Vienna on 4 November 2014.

8min read    
Key Take-Away:

This study interprets the correlation between knee pain and lower back pain (LBP) among young baseball players. To treat LBP among these players, clinicians are suggested to be attentive to the complaints of knee pain from the players. The study also indicated that the point prevalence of LBP and knee pain was 8.4% and 13.1% respectively.

Introduction:

Considerable research has aimed at shoulder and elbow injuries among baseball players; but, as lumbar spine and knee injuries are commonly experienced, they are less frequently studied. During usual motions in baseball, like throwing, hitting, and running, energy is transferred from the lower extremities through the lower back to the upper body. Lower extremity pain and lower back pain (LBP), can hinder the kinematic chain, and it is crucial to understand the association between lower extremity complaints and LBP. The purpose of this study was to interpret the association between knee pain and LBP among young baseball players.

8min read    
Key Take-Away:

Recently, many studies have reported new biomarkers to identify RA, for example, osteoprotegerin (OPG), osteocalcin (OCN) and osteopontin (OPN). This study revealed that the plasma/serum OPG, OCN and OPN levels were almost similar in RA and OA patients. Hence, it may stipulate that race may correlate with OPG, OCN and OPN levels in rheumatoid arthritis (RA) patients. Also, the expression of OPN in RA patients was significantly higher than in OA patients.

Introduction:

Presently published data considering the potential role of OPG, OCN and OPN to distinguish between RA and OA are contradictory. To derive a more precise evaluation, this meta-analysis was performed.

7min read    
Key Take-Away:

The CGRP monoclonal antibody Erenumab, galcanezumab, and fremanezumab reduced of migraine days. CGRP monoclonal antibodies found to be effective as well as safe for preventive treatment of episodic migraine. Although, whether it can improve the quality of life for patients with migraine may be more crucial and is still unknown.

Introduction:

This meta-analysis evaluated the efficacy and safety of monoclonal antibodies against calcitonin gene-related peptide (CGRP) for episodic migraine prevention.

7min read    
Key Take-Away:

Calprotectin has long been identified as an inflammation-related protein which is also active in both innate and adaptive immune responses in inflammation. This study describes that the baseline calprotectin level in serum was positively concerned with expressions of IL-1β, IL-17 and TNF-α in AS patients. Hence, a more significant and more rapid change in calprotectin might indicate a reduction of inflammation in AS patients post-treatment, which might envisage a better response to treatment.

Introduction:

To examine the association of serum calprotectin with risk and severity of ankylosing spondylitis (AS), and to investigate its levels for predicting the treatment responses.

8min read