Abstracts

Key Take-Away:

The study results confirm that tocilizumab (TCZ) mono or combined therapy found to be safer and exhibited remarkable cardiovascular safety. A significant reduction of chemerin and increase of adiponectin in serum was observed in the patients subjected to the analysis.

Introduction:

Adipokines play an essential part in the pathophysiology of rheumatoid arthritis (RA), provide a link between the disease and overweight, explaining the enhanced cardiovascular (CV) risk. It also influences the response to disease-modifying antirheumatic drugs (DMARDs). This study aimed to determine the possible effects of intravenous (IV) tocilizumab (TCZ), an interleukin-6 receptor antagonist, on the serum levels of leptin, adiponectin, resistin, visfatin, and chemerin.

8min read    
Key Take-Away:

The study affirms that the hybrid technique of fixation with osteochondral autograft transfer exhibited positive short-term outcomes and a low complication rate in patients with partially salvageable Osteochondritis Dissecans (OCD) lesions of the knee.

Introduction:

This retrospective case series explains a hybrid fixation method and determined the knee function, clinical outcomes, and activity level of patients when followed for short-term.

8min read    
Key Take-Away:

Statins have significant anti-inflammatory and immune-modulating effects. The study results confirmed that the use of statins specifically atorvastatin significantly lowered the risk of developing knee pain, which could have promising future benefits for knee osteoarthritis management.

Introduction

Statins have various pleiotropic effects, but the literature concerning the possible relationship between statins use and outcomes in knee osteoarthritis (OA) is scarce. The study investigated whether statins use associated with a lower risk of radiographic (ROA), radiographic symptomatic knee OA (SxOA) and pain in North American people.

7min read    
Key Take-Away:

This study shows that the root migration was less in coronectomy with adjunctive guided bone regeneration (GBR) than to coronectomy alone. Moreover, the chance of long-term (3 years or more) root exposure and the need for a following second operation to efface the exposed root would be decreased.

Introduction

Root migration is one of the most common complications during the molar coronectomy, and a portion of the root may be exposed in the oral cavity. This study distinguished the root migration rate, surgical morbidities after third molar coronectomy with or without adjunctive GBR.

8min read    
Key Take-Away:

The study results affirm that there is a high prevalence of small fiber pathology (SFP), in fibromyalgia. The study also provides evidence about the involvement of a distinct phenotype involving SFP in fibromyalgia. Moreover, this is probably the first study to collate data on the overall prevalence of SFP in fibromyalgia.

Introduction

Fibromyalgia is a condition which exhibits widespread chronic pain with neuropathic pain features and has a significant impact on health-related quality of life. The pathophysiology of the disease remains unclear. However, there is increasing evidence for the involvement of the peripheral nervous system with a high prevalence of small fiber pathology (SFP). This systematic literature review aims to establish the incidence of SFP in fibromyalgia.

8min read