Key Take-Away:

Radiofrequency thermocoagulation connected with anhydrous ethanol (AE) chemical blockade of the Multi-segmental Lumbar Sympathetic Ganglia was safe and effective. Nevertheless, the details underlying analgesic mechanisms still need to be investigated.  

As the quality of life is improving, the incidence of diabetes is increasing. Epidemiologists have suggested that the global prevalence of diabetes will reach 552 million by 2030. The rise in the incidence of diabetes leads to an increase in the rate of its complications.

Ding et al. Journal of Pain Research 2018:11 1375–1382
23min read    
Key Take-Away:

The degree of stress shielding is not correlated with patient demographics, radiographic, or implant factors in dysplastic hips, as explained in this study. Considering radiographic bone changes around the stem, spot-weld formation (75.4%) was commonly noted at the border of the distal polished end (zones 3 and zone 5). The results of this study were nearly the same as previously published work depicting that bone remodeling occurred beyond the proximal metaphyseal area.

Introduction:

This study aimed to examine the long-term performance of tapered one-third proximally coated stems in patients with dysplastic hips.

7min read    
Key Take-Away:

Joint pain and stiffness are hallmark symptoms of rheumatoid arthritis (RA), which often worse in the morning upon waking. Hekmatpou D et al. conducted a randomized clinical trial which showed that olive oil has lower expenditure and commonly found in homes as compared to other medical ointments for RA.

 

Introduction:

This study was based on a randomised clinical trial which aimed to determine the efficacy of olive oil for the management of morning inflammatory pain of phalanges and knees among women with RA.

7min read    
Key Take-Away:

In this study, autoantibody status was not connected with early remission in newly diagnosed RA-patients receiving MTX in real-world clinical practice. Hence, the results from this study do not support the hypothesis that treatment should be modified to autoantibody status when it comes to starting MTX therapy as the first-line anti-rheumatic treatment. The results of this study specify that MTX is useful as an initial treatment strategy, notwithstanding the autoantibody status. 

Introduction:

The relationship between autoantibody status and treatment response to methotrexate (MTX) remains unclear in RA. The authors investigated the connection between autoantibody status and early remission in newly diagnosed RA patients treated with MTX using real-world data.

7min read    
Key Take-Away:

Ettore Silvagni et al. favoured the currently recommended use of disease-modifying antirheumatic drugs (bDMARDs) in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), revealing a higher risk of drug withdrawal for TNFi monotherapy as compared to the combination. It suggested that, among bDMARDs, etanercept (ETA) should be preferred over INF and to a lesser extent Adalimumab (ADA) when a first-line monotherapy is a requisite. The study results strengthen the positive influence of Methotrexate (MTX), leflunomide (LFN) or combination of csDMARDs in ameliorating the bDMARDs persistence. 

Introduction:

These analyses focus to comparatively examine the persistence on the treatment of different bDMARDs when administered in monotherapy compared with combination with csDMARDs in rheumatoid arthritis (RA) patients receiving first-line biologics.

 

9min read