Key Take-Away:

Endoscopic sinus surgery (ESS) is helpful for the treatment of chronic rhinosinusitis refractory to the conservative measures. In this trial, used as an adjunct to standard perioperative methods to reduce blood loss, the total intravenous anesthesia (TIVA) in comparison with volatile anesthetic improves intraoperative visualization during ESS.

Introduction:

Bleeding during endoscopic sinus surgery (ESS) can impede visualization and delay the surgical progress. The role that the anesthetic technique may have on the quality of the surgical field during ESS has been previously studied. But, the meta-analyses have considered the current literature inconclusive and lacking methodological consistency. This study was devised keeping these critiques in mind to assess the effect of TIVA versus inhaled anesthetic on the quality of surgical field during ESS.

8min read    
Key Take-Away:

This study reported that tofacitinib 10mg + MTX and baricitinib 4mg + MTX were the most efficacious interventions for rheumatoid arthritis patients with inappropriate response to disease-modifying anti-rheumatic drugs (DMARDs) or biologics therapy. Also, they were not associated with a significant risk of SAEs. But, long-term studies are awaited in a large number of patients with active RA that is inadequately responsive to MTX or biologics to determine the relative efficacy and safety of tofacitinib and baricitinib.

Introduction:

The relative efficacy and safety of tofacitinib and baricitinib were investigated in RA patients with an inadequate response to DMARDs or biologics.

8min read    
Key Take-Away:

This study, based on an international survey emphasis on the difficulty in establishing an unambiguous concept of difficult-to-treat rheumatoid arthritis (RA), which is seen as a heterogeneous condition and not fully covered by current EULAR recommendations. A more detailed survey is still needed to study the management of difficult-to-treat RA further and the recently established EULAR Task Force will explore the management of difficult-to-treat RA.

Introduction:

Patients with difficult-to-treat RA remain symptomatic despite treatment as per the current European League Against Rheumatism (EULAR) management recommendations. These aim at early phases of the disease and pharmacological management. The researchers tried to identify the characteristics of difficult-to-treat RA and issues in its management that are not covered by the current management recommendations.

7min read    
Key Take-Away:

Pregnancy modifies the immune state, most likely causing a change in the course of rheumatoid arthritis (RA). Hissay Aljary et al. evaluated in their cohort study that pregnant women are at a greater plausibility of adverse maternal and neonatal outcomes and they should also be made well-informed of these risks.
 

Introduction:

To investigate whether pregnancies in women with rheumatoid arthritis (RA) are at a higher risk of adverse maternal and neonatal outcomes.

7min read    
Key Take-Away:

This retrospective case series by Guo C et al. reported that supramalleolar osteotomy with intra-articular osteotomy had relatively good clinical results in the treatment of malunited medial impacted ankle fractures for maintaining ankle function. This is the right choice for the treatment of malunited medial impacted ankle fractures related to varus deformity. But, the surgeons should be aware of the loss of ankle motion post-operatively in most patients.

Introduction:

Malunion of a medial impacted ankle fracture may lead to varus ankle deformity. The use of supramalleolar osteotomy plus intra-articular osteotomy in patients with malunited medial impacted ankle fractures was explored in this study.

7min read