Key Take-Away:

A longitudinal interaction between pain interference and depression with the burden of headache in individuals with chronic tension type headache (CTTH) was found.

A tension-type headache (TTH) is the third most prevalent pain condition with an estimated prevalence of 42%. In 2010, the general costs for treatment of headache, most related to migraine and TTH, in Europe was €13.8 billion. 

J Headache Pain. 2017 Dec 28;18(1):119
29min read    
Key Take-Away:

The analysis discovers moderate – quality evidence regarding manipulation and mobilization therapies role in lessening pain and disability with complete safety.

Low back pain is counting among the diseases which cause most devastation in a person's life. About 23% of the population suffering from low back pain. Out of which, 11%–12% population exhibit disability due to severe pain. The management of low back pain involves various modalities; pharmacological as well as non-pharmacological. One section of doctors prefer pharmacological approaches like steroids, NSAIDs, neurotropic, opioid or surgery, While other choose non-pharmacological approaches as these associated with lesser adverse effects. 

Spine J. Author manuscript; available in PMC 2018 Jun 27
26min read    
Key Take-Away:

Both dynamic contrast-enhanced MRI (DCE-MRI) and RA MRI Score (RAMRIS) measures were equally sensitive to treatment effects with Infliximab.

With the technology advancements over the past decade, the treatment options for rheumatoid arthritis (RA) have expanded markedly. However, the acceptable duration for placebo control has also shortened, with rescue therapy typically offered within 14–16 weeks.

PLoS One. 2017 Dec 13; 12(12):e0187397
32min read    
Key Take-Away:

Dexmedetomidine-ketamine combination is a safe alternative for sedation during the cardiac catheterization procedure without the incidence of any hemodynamic or respiratory effects. However, it is associated with some delayed recovery. 

Management of children with congenital heart disease is challenging for anesthesiologists, especially during cardiac catheterization. 

Joshi VS, Kollu SS, Sharma RM. Ann Card Anaesth 2017;20:422-6
18min read    
Key Take-Away:

There is moderate-to high-quality evidence that anticonvulsants are ineffective for the treatment of low back pain or lumbar radicular pain. There is high-quality evidence that gabapentinoids have a higher risk of adverse events.

Globally, millions of people are suffered from low back pain (LBP) and become a major cause of disability than any other health complication. It is predicted that about 5% to 10% of patients with LBP have sciatica and followed by leg pain.

CMAJ. 2018 Jul 3;190(26):E786-93.
18min read