After the warning issued by the Food and Drug Administration (FDA) recently that the uses of general anesthesia or sedation drugs in young children may harm brain development, some pediatricians are worried that parents may delay important surgeries and thus risktheir childrens life. The warning highlighted the repeated use of general anesthesia in children under 3 years old, or a one-time use during surgery that lasts three hours or more. For the pregnant women, these warnings are applicable to women in their third trimester. As per the recent studies, a single use of anesthesia for a short period is unlikely to have negative effects.
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Peripheral inflammatory arthritis is among the most common features with which patients are presented in the rheumatology clinic. Identification of this underlying disease can be difficult and in clinical practice, early inflammatory arthritis is frequently undifferentiated. The European League Against Rheumatism (EULAR) recommendations for the management of early arthritis have been published. In 2010, EULAR presented recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs (DMARDs) which was updated in 2013.
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The U.S Food and Drug Administration (USFDA) has given approval for Maci (autologous cultured chondrocytes on the porcine collagen membrane) for the repair of symptomatic, full thickness cartilage defects of the knee in adults. Maci is the first FDA-approved product which was applied to the process of tissue engineering to grow cells on scaffolds using the healthy cartilage tissue from the patient's own knee.
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The authors of ‘2016 updated the European League Against Rheumatism (EULAR) evidence-based recommendations for the management of gout’ were commended to advocate the use of allopurinol at a lower dose in patients with normal renal function. Specially, this help understand an approach to potentially decrease the risk of precipitating flares of gout early in the course of urate lowering, and perhaps to decrease the risk of severe cutaneous reactions (SCARs) compared with higher initial doses of allopurinol. It was also noted that the authors did not furnish a recommendation on starting dose for patients with renal impairment, the patient group most likely to get advantage from starting at a much lower dose of allopurinol.
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Migraine is a moderate or severe headache that occurs as a throbbing pain on one side of the head or sometime both sides, and it is often accompanied by nausea, increased sensitivity to light, vomiting, blurred vision, and emesis Migraine is the 3rd most prevalent and 6th most disabling ailment in the world. However, the prevalence of migraine varies with the age. Females between 35 and 45 years old exhibits the highest prevalence of migraine.
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