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As per recent research led by scientists of Sichuan Provincial People's Hospital and People's Hospital of Aba China, the diabetic peripheral neuropathy (DPN) shows significant associations with brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) serum levels. DPN is a condition of autonomic and peripheral nerve injury due to diabetes mellitus.

7min read    

According to the research presented at American Headache Society Annual Meeting, San Francisco, Greater occipital nerve block (GONB) may demonstrate as an efficient method to treat moderate to severe headache among emergency department (ED) patients with an acute migraine and on standard therapy with intravenous metoclopramide. Of the ED patients, only 25% succeeded to attain freedom from headache, despite the fact which medicine they received.

8min read    

The novel polymethylmethacrylate (PMMA)-augmented bone cement-injectable cannulated pedicle screw (CICPS) proves to be very efficient and a safe approach to manage osteoarthritis associated thoracolumbar vertebral compression fractures (AO type A), research published in the Journal, World Neurosurgery. CICPS is a most extensively used approach to posterior fixation of patients' vertebrae.

7min read    

According to a recent study of Clinical and Experimental Rheumatology, Tocilizumab (TCZ), an interleukin-6 receptor antagonist, found to have good cardiovascular safety as it significantly regulates the adiponectin and chemerin serum levels, without affecting treatment response among rheumatoid arthritis (RA) patients. Adipokines have an essential part in rheumatoid arthritis pathophysiology and present a connection between the disease and overweight.

7min read    

As the evaluation of disease activity in obese rheumatoid arthritis (RA) patients is challenging, a study was recently carried out to examine the measures set by the American College of Rheumatology (ACR) used in assessing RA disease activity with the specific focus on the swollen joint count (SJC).

7min read    
Key Take-Away:

The results of the study conclude that both LMA and LTS-D are suitable and useful for airway treatment in patients breathing spontaneously during general anaesthesia for minor surgery of short duration.

The laryngeal mask airway LMA and laryngealube suction-disposable (LTS-D) is the second generation single-use supraglottic airway devices (SADs) with gastric access that are used for management of airway during general anaesthesia in spontaneously and mechanically ventilated patients.

Somri M et al. J Anaesthesiol Clin Pharmacol 2018;34:182-7
12min read    
Key Take-Away:

The results of this study indicate the use of the unloading knee brace in combination with usual care as a safe and superior therapy in relieving global pain and improving motion as compared to routine care.

Knee osteoarthritis (OA) refers to a common disabling disorder that leads to considerable pain, immobility, functional impairment and reduced quality of life. It becomes prevalent as the age of the population increases.

Philippe Thoumie et al. Scientific Reports. (2018) 8:10519
15min read    
Key Take-Away:

The study concluded that the calcitonin gene-related peptide provoke cluster headache attacks in active-phase episodic cluster headache and chronic cluster headache but not in remission-phase episodic cluster headache. These results suggest anti-CGRP drugs may be useful in cluster headache management.

Cluster headache is a chronic headache disorder with a prevalence of 0.5 to 1.0 out of the population of 1000. Cluster headache attacks are characterised by prominent ipsilateral cephalic autonomic symptoms (CAS), such as tearing, conjunctival redness, rhinorrhea or nasal congestion, ptosis, as well as the sense of agitation or restlessness. Most of the patients experiencing episodic cluster headache with month-long attack periods separated by remission periods. The remaining 10% to 15% of patients experience chronic cluster headache. Extended cluster headache periods dramatically hinders individuals with increased health care expenses. The initiating pathways for the cluster periods and individual attacks are still unknown. There is no doubt that treatment options are limited, and no disease-specific preventive medication exists.

JAMA neurology. 2018 Jul 9.
24min read    
Key Take-Away:

The study results confirm that tocilizumab (TCZ) mono or combined therapy found to be safer and exhibited remarkable cardiovascular safety. A significant reduction of chemerin and increase of adiponectin in serum was observed in the patients subjected to the analysis.

Introduction:

Adipokines play an essential part in the pathophysiology of rheumatoid arthritis (RA), provide a link between the disease and overweight, explaining the enhanced cardiovascular (CV) risk. It also influences the response to disease-modifying antirheumatic drugs (DMARDs). This study aimed to determine the possible effects of intravenous (IV) tocilizumab (TCZ), an interleukin-6 receptor antagonist, on the serum levels of leptin, adiponectin, resistin, visfatin, and chemerin.

8min read    
Key Take-Away:

The study affirms that the hybrid technique of fixation with osteochondral autograft transfer exhibited positive short-term outcomes and a low complication rate in patients with partially salvageable Osteochondritis Dissecans (OCD) lesions of the knee.

Introduction:

This retrospective case series explains a hybrid fixation method and determined the knee function, clinical outcomes, and activity level of patients when followed for short-term.

8min read    
Education
Smart Guidelines

Pain is the leading cause of suffering, disability and medical care worldwide.

10 min read    
Education
Presentations

Arthritis encompasses more than 100 different arthritic conditions which are a chronic, painful, and debilitating group of diseases.

15 min read    
Education
Presentations

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with an estimated prevalence of 0.5-1% of the population worldwide; it is also reported that women are more affected than men are. [1].

15 min read    
Education
Presentations

Vitamins are organic compounds essential for normal physiological functions.

15 min read    
Education
Presentations

The World Health Organization (WHO) describes the rational use of medicines as, “patients receive medications appropriate to their clinical needs, in doses that meet their own individual requiremen

5 min read    
March 19, 2019

As per recent research led by scientists of Sichuan Provincial People's Hospital and People's Hospital of Aba China, the diabetic peripheral neuropathy (DPN) shows significant associations with brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) serum levels. DPN is a condition of autonomic and peripheral nerve injury due to diabetes mellitus.

Key Take-Away:

The results of the study conclude that both LMA and LTS-D are suitable and useful for airway treatment in patients breathing spontaneously during general anaesthesia for minor surgery of short duration.

The laryngeal mask airway LMA and laryngealube suction-disposable (LTS-D) is the second generation single-use supraglottic airway devices (SADs) with gastric access that are used for management of airway during general anaesthesia in spontaneously and mechanically ventilated patients.

Somri M et al. J Anaesthesiol Clin Pharmacol 2018;34:182-7
12min read    
Education
Smart Guidelines

Pain is the leading cause of suffering, disability and medical care worldwide. Pain associated with chronic diseases are not life-threatening, but people continue to live with this pain in developed and developing countries affecting their overall quality of life.

10 min read