Vitamin D supplementation for the management of knee osteoarthritis: Results of systematic review

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Vitamin D supplementation for the management of knee osteoarthritis: Results of systematic review
Key Take-Away: 

The present systematic review supports the use of Vitamin D supplementation in knee osteoarthritis (OA). 

Osteoarthritis is the most usual form of arthritis and it causes disability and affects the overall quality of life.

ABSTRACT: 
Background: 

Osteoarthritis is the most usual form of arthritis and it causes disability and affects the overall quality of life.

Various treatment options are considered for OA, but conflicting evidence exists concerning the supplementation of vitamin D in knee OA. The present systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee OA.

Methods: 

An electronic literature search was done in databases including PubMed, Embase, and Cochrane CENTRAL from inception to 6th July 2016.

The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered a change in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure. Change in tibial cartilage thickness, joint space width, and the safety profile was considered as secondary outcomes. Participants were randomized either to treatment or placebo group. Participants received cholecalciferol as an intervention through oral route in the dose range of 800–60,000 IU except in the one study where participants received ergocalciferol.

Results: 

All included RCTs showed a significant increase in serum vitamin D level in the treatment group compared to the placebo group.

No significant reduction in pain and function was reported on WOMAC scale except in one study. No significant difference was reported for WOMAC stiffness in any study. Three studies assessed VAS of which two showed statistically significant improvement in the knee pain. Three of the RCTs reported safety data with one incidence of calculus ureteric and hip fracture was found to be related to the drug.

Conclusion: 

The study found evidence from RCTs to be insufficient to support the use of vitamin D supplementation for patients with knee OA.

Source:

Rheumatology International

Link to the source:

https://link.springer.com/article/10.1007%2Fs00296-017-3719-0

The original title of the article:

Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials

Authors:

Salman Hussain et al.

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