Vitamin D levels and the risk of total fracture and hip fracture

Primary tabs

NEWS
Vitamin D levels and the risk of total fracture and hip fracture

Osteoporosis can lead to severe outcomes of hip fracture, or it may be total fracture, which might be affected by serum 25-hydroxyvitamin D (25(OH) vitamin D) level in the body. But the results showing association between serum 25(OH) vitamin D level and the risk of fractures are still controversial.

Recently a meta-analysis was conducted to estimate the relationship between serum 25-hydroxyvitamin D (25(OH) vitamin D) level and the risk of total fractures and hip fractures. The relevant studies from their inception to June 1, 2016, were included by searching the PubMed, EMBASE, and OVID databases. Published prospective cohort or nested case-control studies assessing the association of serum 25(OH) vitamin D level with the fracture risk were included. A total of 16 prospective cohort studies and 3 nested case-control studies were included. The data abstraction was done by two reviewers independently. Relative risks (RRs) with 95% confidence intervals (CIs) was obtained during the whole analysis.

It was found that there was significant association between low serum 25(OH) vitamin D level and the risk of total fractures (RR 1.25, 95% CI 1.06-1.43; 2 = 31.3%, p for heterogeneity = 0.15) and hip fractures (RR 1.48, 95% CI 1.29-1.68; I 2 = 0%, p for heterogeneity = 0.51). There was 40% increase in hip fracture for each SD decrease in serum level of 25(OH) vitamin D (RR 1.40, 95% CI 1.20-1.61; I 2 =0%, p for heterogeneity = 0.51). But no association was found between each SD decrease in serum 25(OH) vitamin D level and the increased risk of total fractures (RR 1.14, 95% CI 0.93-1.35; I 2 = 63.2%, p for heterogeneity = 0.04).

The study shows the association between low serum 25(OH) vitamin D level and increased risks of total and hip fractures. In all the examined studies, the per SD decrease in serum 25(OH) vitamin D level was found to be linked to the increased risk of hip fracture but not with the risk of total fractures.

Source:

Osteoporosis International

Link to the source:

https://link.springer.com/article/10.1007%2Fs00198-017-3955-x

Original title of article:

The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture

Authors

Lee M, Zhu F, et al.

SearchTags: 
Exploratory, 25-hydroxyvitamin D, Osteoporosis, Hip joint, Meta-analysis
Log in or register to post comments