Urinary proteomics can define distinct diagnostic inflammatory arthritis

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Urinary proteomics can define distinct diagnostic inflammatory arthritis

Current diagnostic measures for inflammatory arthritis lack the required specificity to appropriately divide patients. Thus, new methods to categorise patients with these conditions need to be explored.

The present study explained whether urinary proteomic biomarkers specific for various forms of arthritis (rheumatoid arthritis; RA, psoriatic arthritis; PsA, osteoarthritis; OA or chronic inflammatory conditions like inflammatory bowel disease; IBD) could be recognised.

Overall, 50 participants per group with RA, PsA, OA or IBD and 50 healthy controls were inculcated in the study. About two-thirds of these populations were randomly assigned as a training set, while the rest one-third were reserved for validation. Multiple urinary peptides significantly associated with discrete pathological conditions were revealed as a result of sequential comparison of one group to the other four. The classifiers for the five groups were made and tested blind in the validation test set.

These classifiers portrayed superb performance, with an area under the curve between 0.90 and 0.97 per group. The identified peptide markers revealed novel inflammatory markers along with dysregulation of collagen synthesis and inflammation.

Therefore, it was concluded that urinary peptide signatures could efficiently differentiate between chronic arthropathies and inflammatory conditions with distinct pathogenesis.

Source:

Scientific Reports

Link to the source:

https://www.nature.com/articles/srep40473

Original title of article:

Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups

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