Upcoming autoantibody testing technologies for rheumatic diseases detection

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Upcoming autoantibody testing technologies for rheumatic diseases detection

The groups of disorders involved malfunctioned immune system referred to as autoimmune diseases. One of the classes of problems categorized under the autoimmune diseases is systemic autoimmune rheumatic diseases (SARD) comprising of diseases like Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (Ssc) etc.

The basic diagnosis of these rheumatic diseases is done on the basis of antinuclear antibodies existence. Antinuclear antibodies (ANA) are the group of antibodies.
The antinuclear antibody test involved in this study is standard slide-based indirect immunofluorescence (IIF). However, this technique reflected weak specificity towards SLE & some other SARD. Due to which, other immunoassay techniques with upgraded diagnostic and prognostic information used for evaluation. Some of these tests also had entered clinical practice.
The whole study sums up with ANA testing & multiplex techniques current state for evaluating auto-antibodies, approaches for applications in early disease stages and probability of point-of-care testing.


Arthritis Research & Therapy201719:172

Link to the source:


Original title of article:

Emerging technologies in autoantibody testing for rheumatic diseases


Nancy J. Olsen et al.

Diagnostic, Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis, Systemic autoimmune rheumatic diseases (SARD), Joint, Review, Slide-based indirect immunofluorescence (IIF) test
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