Unique Antidepressant and Anxiolytic effects of Diclofenac, Ketoprofen and Naproxen in patients with Pain

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Unique Antidepressant and Anxiolytic effects of Diclofenac, Ketoprofen and Naproxen in patients with Pain

Ketoprofen, Diclofenac and Naproxen have shown to decrease reports of depression and anxiety by a factor of 2.32 and 2.86, 2.22 and 2.13, and 1.92 and 1.23 respectively, findings from a  recent population scale retrospective analysis.

Depressive disorders represent the third leading disease group contributing to the global disease burden. The lifetime incidence of depression ranges between 8–12% in the majority of the industrialised countries.

Antidepressant and anxiolytic drugs used these days do not provide adequate relief in over one-third of patients due to delayed and variable therapeutic effect, adverse effects preceding the therapeutic action, and adherence problems. A strong link has been noticed between treatment-resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid. Also, prior research has confirmed the comorbidity of depression and anxiety with pain and inflammation but its still remains unclear if anti-inflammatory treatment is beneficial for the patients with depression and anxiety due to pain.

In the present study, a total of 430,783 FDA adverse effect reports of patients treated for pain were analyzed to recognize possible antidepressant and anxiolytic effects of various anti-inflammatory drugs. Patients treated for depression or consuming any known antidepressants were not included in the analysis.

The odds ratio analysis of 139,072 NSAID reports unveiled that ketoprofen, diclofenac and naproxen were linked to the decreased reports of depression and anxiety. There was no antidepressant and anxiolytic effect observed with other NSAIDs.


PLOS one

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The original title of the article:

Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain



Makunts; T. et al.

Therapeutic, Diclofenac, Ketoprofen, Naproxen, Depression, Antidepressants, Adverse effect
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