Two different doses of pregabalin and lidocaine in pain after propofol injection have comparable effects

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Two different doses of pregabalin and lidocaine in pain after propofol injection have comparable effects

Pregabalin is a synthetic molecule derived from gamma-amino butyric acid (GABA) inhibitor that possesses anticonvulsant and analgesic effects. Lidocaine/  xylocaine / lignocaine is a medication used to numb the tissues of a specific area. An intravenous (iv) anesthetic- propofol often causes pain on injection, which can cause distress to patients. The study mentioned here is a randomized, double-blind, prospective trial, performed to investigate the analgesic effect of pregabalin on pain following propofol injection, compared with lidocaine.

A total of 120 patients were randomized into 3 groups, each containing 40 patients. is. They received oral placebo and lidocaine (iv) 40  mg with venous occlusion for 1 minute (group L, n = 40), oral pregabalin 75 mg and intravenous normal saline with venous occlusion for 1 minute (group LP, n = 40), and oral pregabalin 150 mg and intravenous normal saline with venous occlusion for 1 minute (group HP, n = 40) as pretreatment, followed by administration of 1% propofol 0.5  mg/kg. On a 4-point scale (0 = no, 1 = mild, 2 = moderate, and 3 = severe pain), the pain intensity was measured. During the first 24 hours after the surgery, any side effects associaated with pretreatment subtances were measured.

The demographic data was similar between all the three groups. The prevalence of pain following propofol injection was remarkably reduced in group HP (50%) and group L (55%) compared with group LP (92.5%) (P < 0.05) respectively. The occurence of moderate pain in group HP (12.5%) and group L (15%) were significantly decreased as distinguished from group LP (37.5%; both, P < 0.05). There were no significant differences in the incidence of side effects like headache and dizziness between the groups. It was found that the pretreatment with oral pregabalin (150 mg) and i lidocaine (40  mg; iv) with venous occlusion equally reduced the pain from propofol injection.

Source:

Medicine

Link to the source:

https://www.ncbi.nlm.nih.gov/pubmed/28002316

Original title of article:

Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection: A double-blind, randomized clinical consort study.

Authors:

Eunkyung Choi et al.

Medicine
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