Treatment of hyperuricemia with benzbromarone’s beneficial antioxidant properties
A significant antioxidant effect against oxidative stress has been found to be associated with uric acid. However, an increase in oxidative stress via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in adipocytes and vascular cells, has been seen with uric acid.
Oxidative stress is generated with the involvement of uric acid transporter 1 and uric acid also activates the renin-angiotensin system, producing angiotensin II and subsequently increasing intracellular oxidative stress.
A recent study reported the suppression of uric acid reabsorption via uric acid transporter 1 inhibition in renal tubular cells with benzbromarone. The investigators of the study assessed in vitro antioxidant effect of benzbromarone from numerous outlooks. Chemiluminescence assay and electron paramagnetic resonance spectroscopy were used to measure the direct radical-trapping capacity of benzbromarone. After that, the intracellular antioxidant activity of benzbromarone in hyperuricemia was evaluated using endothelial cells.
Considering results, benzbromarone was assumed to directly scavenge the superoxide anion radical. Also, it inhibited reactive oxygen species production that was induced by angiotensin II or uric acid in endothelial cells. This study well explains the uricosuric properties of benzbromarone which is well tolerated and highly effective in providing beneficial properties for hyperuricemia treatment. Also, the main emphasis is laid on the oxidation inhibition parameters related to this treatment.