Statins could reduce mortality in patients with arthritis

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Statins could reduce mortality in patients with arthritis

According to a new study, researchers from the Massachusetts General Hospital have revealed that patients with ankylosing spondylitis or psoriatic arthritis who take statin therapy could reduce mortality risks by 33% as compared to those not on the medications. People suffering from arthritis may experience considerable benefits if they take statin, a class of drug known to help control cholesterol levels in the blood.

The present study was aimed to see if initiation of statins might be associated with a lower mortality risk in this patient population. As per Oza A, a rheumatologist at Massachusetts General and a lead author of the study along with Na Lu and Hyon Choi, “The expanding literature on the dual-role of statins to lower both inflammation and cholesterol levels has naturally led to interest in the role of statins in inflammatory arthritis." A randomised trial found such dual benefit among patients with rheumatoid arthritis, and a population-based study of patients with rheumatoid arthritis found a survival benefit associated with statin use as well.

In order to determine whether statins may reduce mortality in patients with these forms of psoriasis, researchers analyzed the data from a UK database. They identified 2904 patients with ankylosing spondylitis or psoriatic arthritis between January 1, 2000 and December 31, 2014. These patients were compared with the same number of people with these types of arthritis who were not currently taking statins. Fifty different variables including disease duration, socioeconomic status, body-mass index, lifestyle factors and medication use were studied.

During the follow-up, 271 patients taking statins had died, while 376 patients who were not taking the drug had died. Based on this data, the researchers concluded that those patients on statin therapy faced a 33 percent lower risk of all-cause mortality, compared to arthritis patients not using the drugs.  This suggests that statins may be beneficial in this patient population to lower the risk of all-cause mortality.

This observational study improves the possibility that clinicians may have a lower threshold for starting their patients on statins to mitigate this mortality risk. To that effect, it sets the groundwork for potential clinical trials to come, which will provide high-level evidence about the impact statins have on their health. Howver, further research is required to determine the true benefits of statins in this disease to reduce mortality and other cardiovascular cause.


Spinal news international

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Statins may lower mortality risk in ankylosing spondylitis patients


Amar Oza

Spinal news international
Therapeutic, Statins, Ankylosing spondylitis, Psoriatic arthritis, Review, Safety, Mortality rate
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