Significance of moderate weight loss in knee osteoarthritis in overweight and obese females
Knee is the most susceptible joint effected by the attack of osteoarthritis (OA) leading to pain and inflammation. A study was especially deisgned to study the consequence of moderate amount of weight loss on the incidence of knee OA in middle-aged, overweight and obese women, without considering clinical and radiological knee OA at baseline.
From the PROOF study (ISRCTN 42823086), overall 353 women (87%) with follow-up data were specified which estimated the preventive effect of a diet and exercise intervention and of oral glucosamine sulphate on the occurence of knee osteoarthritis. The prevalence of knee OA was distinguised from the women who reached the clinically relevant weight loss (WL) target of 5 kg or 5% of body weight after 30 months and those who did not reach this target (N-WL).
As per the results, WL group depicted a significantly lower incidence of knee OA according to the primary outcome measure, included knee OA according to ACR criteria (clinical and radiographic), K&L grades and joint space narrowing ≥ 1.0 mm (15% vs. 20%; OR 0.5, 95% CI 0.3 – 0.9). Additionally, many beneficial health measures like fat percentage, blood pressure and blood glucose level occured due to loss in weight.
Thus, it can be deciphered from this study that a demotion of ≥ 5 kg or 5% of body weight over a 30 month period reduces the likelihood for the outbreak of radiographic knee OA in middle-aged, overweight and obese women. A longer follow-up period will be important before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant because of the slow progression of this illness.