Serum Caspase-3 level Effectively Predicts Endometriosis Severity

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Serum Caspase-3 level Effectively Predicts Endometriosis Severity

Serum caspase-3 level can be termed as a reliable predictor of endometriosis severity, the new study finds.

Caspases are one of the types of proteases that help to regulate cell death. Kaya C and colleagues conducted the study with an aim to establish the role of caspase-3 in predicting the severity of endometriosis.

A total of 90 females who underwent laparoscopic surgery due to benign ovarian cysts or endometrioma were included in the analysis. These patients were analyzed for serum caspase 3, Soluble Fas Ligand (sFasL) and Annexin A2 (ANXA2) levels to assess endometriosis severity.

Three groups were formed. The first one was the control group that comprised 29 patients; the second involved 29 patients with stage I-II endometriosis and the third involved 30 patients with III-IV endometriosis stages. The levels of caspase-3, sFasL and ANXA2 showed a considerable variation between control and stage II-IV endometriosis stages ( p < 0.001; p = 0.007 and p = 0.022 respectively) and also between I-II and II-IV endometriosis stages ( p < 0.001; p = 0.002 and p = 0.044 respectively). According to receiver operating characteristic analysis, the area under curve was found to be 93% at 10.7 ng/mL cut-off level for caspase-3 with 90% sensitivity and 87% specificity.


Gynecol Obstet Invest


Original title of the article:

The Role of Serum Caspase 3 Levels in Prediction of Endometriosis Severity


Cihan Kaya et al.

Diagnostic, Endometriosis, Uterus
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