Role of Topical Ketoprofen in Acute Ankle Sprain

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Role of Topical Ketoprofen in Acute Ankle Sprain

Soft tissue injuries are the most common injury in sports. Soft tissue refers to the tissues that connect, support or surround other structures and organs of the body. Soft tissue includes muscles, tendons, ligaments, fascia, nerves, fibrous tissues, fat, blood vessels and synovial membranes.

Topical agents have been shown to be effective in soft tissue injuries and commonly used in outpatient clinics. However, the data regarding topical agents in the emergency departments is insufficient and they are not used often in the emergency department setting. Ketoprofen has been shown to be an effective option in the treatment of ankle sprain. Thus, to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in patients presenting with an ankle sprain to the emergency department, a randomized study was conducted.

In the conducted randomized trial, patients are presented with ankle sprain which is composed of the study population. Study patients were randomized into 2 study arms which are 2.5% ketoprofen gel and placebo administered over a 5cm area locally. Pain alleviation was measured by visual analog scale at 15 and 30 minutes. A total of 100 patients were included in the final analysis.

After analysis, the median pain reduction in ketoprofen and placebo groups at 15 minutes were 27 and 9 respectively. The median pain reduction at 30 minutes for both groups was 42 and 20 respectively. Pain improvement either at 15 minutes or 30 minutes was better in the ketoprofen group than placebo. Whereas, there were no adverse effects in the either group.

It was concluded after the analysis that ketoprofen gel was superior to placebo at 30 minutes in alleviating pain secondary to ankle sprain in the emergency department with a high safety profile. However, further studies were still needed concerning the effect of ketoprofen gel for long- term effects.

Foot & ankle international
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