Role of loxoprofen in pain and inflammation

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Role of loxoprofen in pain and inflammation

Loxoprofen is a NSAID (non-steroidal anti-inflammatory drug) and a prodrug of a propionic acid derivative. It has anti-inflammatory and antipyretic properties. Loxoprofen (Sodium) is optically active and marketed as racemic mixture. Loxoprofen is a prodrug type NSAID that is available in several formulations, including 60mg tablets, 100mg hydrogel patches and 50 or 100mg tape.

It is used to manage pain and inflammation associated with musculoskeletal and joint disorders or operative procedures. The drug is rapidly absorbed from the gastrointestinal tract and shows excellent analgesic and anti-inflammatory effects, while this drug is characterized by its relatively lower toxicity to the gastrointestinal tract than other NSAIDs because it is a prodrug showing effects after conversion to active compounds in the body.

In the active comparator-controlled trials, oral loxoprofen therapy provided analgesic efficacy that generally did not significantly differ from that of celecoxib for postoperative pain or frozen shoulder, ibuprofen for knee osteoarthritis or naproxen for lumbar pain. In multicenter trials, loxoprofen hydrogel patches were non-inferior to oral loxoprofen with regard to rates of final overall symptomatic improvement over 1–4 weeks in patients with knee osteoarthritis, myalgia or trauma-induced swelling and pain. It has been observed that loxoprofen hydrogel patches were also non-inferior to other commercially available patches (ketoprofen and indomethacin) over 2 or 4 weeks in patients with knee osteoarthritis or myalgia in open-label studies.

It was concluded that oral and topical loxoprofen were generally well tolerated in clinical trials. Thus, loxoprofen is a useful analgesic option for patients with pain and inflammation, with topical loxoprofen potentially reducing the risk of gastrointestinal, cardiovascular and renal complications associated with oral NSAID use.

Adis Drug Evaluation
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