Researchers uncover connection between arthritis and periodontitis

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Researchers uncover connection between arthritis and periodontitis

Recent review conducted by researchers evaluated the relationship between rheumatoid arthritis (RA), a chronic inflammatory disease of the joints and periodontitis, a chronic inflammatory disease of the gums. It is known that RA is an inflammatory condition that can lead to tooth loss and other health complications.  This association between these conditions has been demonstrated previously as well, but remained contraversial. Therefore, the purpose of the presented meta-analysis was to comprehensively determine the association between RA and periodontitis.

Tang Q and colleagues reviewed the studies showing strong association between periodontitis and  RA. A literature search was performed with PubMed and EMBASE database using search terms related to RA and periodontitis. Eligible studies were extracted using standardized extraction forms and odds ratios (OR) with 95% confidence intervals (CI) was calculated for each study.

A meta-analysis considered eight case control studies and the sample size ranged from 104 to 151,569 participants. It was found that the prevalence of periodontitis in RA patients ranged from 15.5% to 100%, compared with 10.0% to 82.1% in controls. In group 1 (control) and group 2, the heterogeneity was 38% and 11%, respectively. Using fixed-effects analysis, the overall pooled estimates of the ORs for periodontitis were 4.68 (95% CI: 3.11–7.05) and 1.28 (95% CI: 1.24–1.33) in groups 1 and 2, respectively.

Thus, a significant association between RA and periodontitis with greater risk is supported by the results of this meta-analysis of studies comparing RA to control groups.

Source:

The International journal of periodontics & restorative dentistry

Link to the source:

http://www.quintpub.com/journals/prd/abstract.php?article_id=16897#.WGo9JNJ961s

Original title of article:

A Possible Link Between Rheumatoid Arthritis and Periodontitis: A Systematic Review and Meta-analysis

Authors:

Qingqin Tang, Haitao Fu, Baodong Qin, Zhide Hu, Yaoting Liu, Yan Liang, Lin Zhou, Zaixing Yang, Renqian Zhong

The International journal of periodontics & restorative dentistry
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