Proven treatments to prevent migraine
Migraine is a disabling neurological condition. It is the 7th most disabling illness in the world due to its considerable impact on the quality of life of patients. It is is treated with acute and preventive medications. However, some people do not respond to standard treatments.
None of the available pharmacological prophylactic treatments have been designed specifically for this purpose. Therefore, migraine is a major public health problem which is not always effectively managed, indicating the need for additional migraine-specific drugs. This research reviewed the evidence supporting the pharmacological options together with less commonly used invasive and noninvasive treatments.
There are multiple options for the acute and prophylactic management of migraine but some are effective and some are not than others. The choice of a prophylactic agent should be selected according to the patient’s needs and expectations and keeping in mind that these can cause side effects. The acute management of migraine attacks aims at achieving rapid pain relief. In many patients, simple analgesics are the drugs of first choice for migraines of mild or moderate severity. Researchers recommended the use of topiramate, amitriptyline, and propranolol as first-line prophylactics.
However, in the future, it is likely that the noninvasive options such as Transcranial magnetic stimulation (TMS) and Cefaly will become more widely accessible as prices are lowered and beneficial in migraine prevention. Invasive techniques such as percutaneous occipital nerve stimulation (ONS) or supraorbital nerve stimulation (SONS) should be reserved for those who have failed to respond due to the risks associated with these interventions and the lack of long-term data on safety and efficacy.