Progestin with Estrogen Combined Therapy for Endometriosis-Related Complications

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Progestin with Estrogen Combined Therapy for Endometriosis-Related Complications

According to the findings of a latest systematic review analysis conducted by Jeffrey T. Jensen and colleagues, the hormonal contraceptive combination of Progestin and Estrogen reduces endometriosis-related dyspareunia, dysmenorrhea and pelvic pain.

Endometriosis is one of the most prevalent health conditions affecting nearly 1 of every 10 females around the world during their reproductive age. The combined hormonal contraceptive (CHC) agents are often used to provide relief from endometriosis-related complications. However, there is a lack of substantial data showing the efficacy of CHCs in Endometriosis. 

Jeffrey T. Jensen and colleagues analyzed Embase, Derwent Drug File databases and MEDLINE for prospective clinical studies showing the efficacy of CHC treatment in endometriosis management. A total of nine observational studies and nine randomized controlled trials met the inclusion criteria. However, the quality of the evidence was not up to the mark; most trials were non-blinded, and only two were placebo-controlled. The involved interventions were CHC agents, placebo and active comparators. Researchers analyzed their effect on females having endometriosis and recorded endometriosis-related pain as the main outcome of the analysis. 

Most of the trials documented the significant role of CHC agents in minimizing pelvic pain, dyspareunia and dysmenorrhea. A continual administration reflected better outcomes than cyclic administration. A comparative analysis of CHC agents with GnRH agonists and oral progestins was also done. CHC exhibited comparable or lower efficacy as compared to other modalities. 

The present data govern the efficacy of CHC agents in managing endometriosis-related complications but with low-quality evidence. Further research is needed to identify the role of CHC and its comparable effectiveness with other approaches in endometriosis-related pain treatment. 


Fertility and Sterility 

Link to the source:

Original title of article:

Use of combined hormonal contraceptives for the treatment of endometriosis-related pain: a systematic review of the evidence


 Jeffrey T. Jensen et al.

Therapeutic, Progestin, Estrogen, Dysmenorrhea, Pelvic Pain, Pelvis, Lower Abdomen, Contraceptive Pills, Systematic Review, Efficacy
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