Prednisone use in acute complex regional pain syndrome after fracture or injury
Complex regional pain syndrome which usually takes place after fracture is the major reason of pain, dysfunction, and potentially permanent disability. Current studies and several international guidelines have supported the use of oral corticosteroids but still it is not commonly prescribed.
In one of the recent studies, the investigators have tried to evaluate the treatment of complex regional pain in the upper extremity after acute injury as a disease modifying and possibly curative treatment. The investigators presented their study in the form of case series and included 3 patients who developed CRPS after a trauma to the neck and/or upper limb. Clinical examination and bone scan was used to screen the patients. Patients met the Budapest criteria.
All the three patients experienced a significant decrease in pain, swelling and debility. These findings suggest that prednisone is a promising treatment that may stops the advancement of acute phase of CRPS. However, in order to encourage the widespread use of prednisone, large-scale future studies are desired.