Parathyroid hormone and related protein analogs can be effectively used in osteoporosis management

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Parathyroid hormone and related protein analogs can be effectively used in osteoporosis management

According to recent findings from the study by Lede BZ et al., parathyroid hormone therapy (PTH) is emerging as an effective treatment for bone loss. Moreover, PTH, when given intermittently, has a substantial anabolic effect on bones.

Osteoporosis, a condition in which bone density gets reduces and fragility increases. Further, the thinning of bones with the weak bone crystals formation makes the situation more critical. To stop this loss of bone, treatment is needed.

A study was conducted to evaluate the efficacy and optimal use of parathyroid hormone and parathyroid hormone-related protein analogs in osteoporosis treatment. During the analysis, various parathyroid analogs were found to be effective in bone regeneration. One of the parathyroid hormone analog found was Teriparatide which is a potent stimulator of bone remodeling. This analog increases the bone mineral density and also reduces the risk of vertebral and non-vertebral fractures in postmenopausal osteoporotic women. Further, one more parathyroid analog was found to be very effective in bone regeneration was Abaloparatide. However, pharmacological effects of Abaloparatide was found to be different from Teriparatide, particularly in cortical bone. Further, it was analyzed that these analogs exhibited better effects when used in combination with a potent antiresorptive medication. The Teriparatide and Denosumab (antiresorptive medication) combination known to enhance bone strength and density effectively than any monotherapy or currently available regimen.

Overall, the study found that parathyroid hormone and parathyroid hormone-related protein analogs were very effective in osteoporosis management. These could provide therapy avenues as monotherapy, in combination with antiresorptive agents or sequence with antiresorptive agents. This does not affect its expanding role. Instead, its activity gets enhanced in combination with antiresorptive agents. 

Source:

Current Osteoporosis Reports

Link to the source:

https://link.springer.com/article/10.1007%2Fs11914-017-0353-4

The original title of the article:

Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs in Osteoporosis Therapy

Authors:

Benjamin Z. Lede et al.

SearchTags: 
Parathyroid hormone, Protein analogs, Osteoporosis, Management
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