Pain perception can be associated with stool consistency

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Pain perception can be associated with stool consistency

For a long time, commensal and pathogenic bacteria have been known to affect a variety of gut functions and in severe cases that may cause constipation and diarrhoea. Therefore, the imbalance in gut microbiome (GM) can be resulted not only due to GI upset like irritable bowel syndrome (IBS) and obesity but may also be sue to neuropsychiatric diseases such as anxiety and schizophrenia. Researchers have reported evidence supporting the association of stool consistency and GM composition with dysbiosis.

In this observational study, Yukiko Shiro et al. included 38 healthy subjects. They were assessed on their usual stool form, constipation, the degree of obesity, pain sensation by a mechanical stimulus, cold pain threshold, and a questionnaire on their psychological states.

The Bristol Stool Form Scale (BSFS) was significantly and positively associated with both pain-VAS 100g and State-Trait Anxiety Inventory Questionnaire (STAI). Body Mass Index (BMI) showed a significant association with Hospital Anxiety and Depression Scale (HADS-D) and STAI. Furthermore, pain-VASs showed a significant positive association with STAI. However, no significant associations were found between the Cleveland Clinic Constipation score (CCS) and an independent variable. Also, it was observed that significant predictors to the pain-VAS 100g were PCS and BSFS, while a predictor to the pain-VAS 600g was BSFS. Moreover, significant relationships were found between HADS-D and BMI, STAI and BSFS, and STAI and BMI.

The results of the present study showed the significant correlation between the pain perception and anxiety status with stool form. Overall, the higher were the pain sensitivity and anxiety status; the looser and more watery was their stool. Moreover, they showed no significant correlation between constipation and pain perception or psychological state.


PLoS One. 2017 Aug 9;12(8):e0182859.

Link to the source:

Original title of the article:

Stool consistency is significantly associated with pain perception


Yukiko Shiro et al

Therapeutic, Pain, Severe, VAS, BSFS, HADS-D, STAI
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