Oral Cholecalciferol (Vitamin D) decreases Menstrual Pain in Patients with Dysmennorhea

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Oral Cholecalciferol (Vitamin D) decreases Menstrual Pain in Patients with Dysmennorhea

According to a study published in 'Gynecological Endocrinology,' the Vitamin-D replacement therapy significantly decreases menstrual pain in dysmenorrheic patients.

Hatice Kucukceran et al. conducted the observational study to investigate the Vitamin-D levels in patients with primary dysmenorrhea and to estimate the effect of Vitamin-D replacement on symptoms. A total of 100 patients aged 18–30 years with primary dysmenorrhea diagnosis were included. Visual analog scale (VAS) was used to assess the pain severity. The 25-hydroxyvitamin D [25(OH)D] levels of the patients were noted, and as per the measurement results, the replacement therapy was utilized. After three months of follow-up, the 25(OH)D levels and the VAS score was examined.

It was found that 25(OH)D levels were insufficient in 23.0%, deficient in 45.0%, and severely deficient in 32.0% of the patients. The VAS score was found to be inversely proportional to 25(OH)D level.

After Vitamin D replacement therapy, a significant reduction was noted in VAS scores in all the three groups. The amount of decrease in VAS score was higher in the patients with severely deficient levels of 25(OH)D as compared to the patients with deficient or insufficient levels. In this study, a significant and negative correlation was established between Vitamin-D and symptoms associated with dysmenorrhea.  


Gynecological Endocrinology

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Original title of the article

The impact of circulating 25-hydroxyvitamin and oral cholecalciferol treatment on menstrual pain in dysmenorrheic patients


Hatice Kucukceran et al.

Exploratory, Cholecalciferol, Menstrual pain, Dysmenorrhea, Vitamin, Observational, VAS
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