Obesity and smoking reduces likelihood of treatment success in early rheumatoid arthritis

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Obesity and smoking reduces likelihood of treatment success in early rheumatoid arthritis

Rheumatoid Arthritis (RA) is a chronic disabling disease which can affect the joints, connective tissues, muscle, tendons and fibrous tissue that causes pain and deformity. The prevalence of RA globally varies between 0.3% and 1%.

People with RA who are nonsmokers and maintains a healthy weight are much likely to achieve sustained remission than those who are overweight and smoke. From the results of a study presented at European League Against Rheumatism Annual Congress (EULAR), 2016 showed that the likelihood of achieving sustained remission in early RA is significantly lower in obese patients and those who smoke. Achieving, a healthy body weight could significantly improve their chance of becoming symptom-free after adequate treatment.

Recommendations from EULAR stated that the remission (absent disease activity) is the main target of treatment in patients with RA. However, many patients failed to achieve or maintain remission within the ten years of disease onset.

Dr. Susan Barlett from McGill University in Montreal, Canada, a study investigator said that “despite the high prevalence of excess body weight and smoking among RA patients, relatively little is known about whether and to what extent these modifiable lifestyle factors impact the likelihood of achieving sustained remission”. Findings showed that not smoking and a healthy body weight-lifestyle factors which can be modified by patients that can have a significant impact on becoming symptom-free.

The independent effects of Body Mass Index (BMI) class and smoking on time to sustained remission in the first three years shortly after diagnosis were estimated in patients with the early RA who had been enrolled into the large real world Canadian Early Arthritis Cohort (CATCH) study. Total 1,008 patients underwent follow-up for three years with the disease activity, patient-reported outcomes and medication assessed at each visit.

One half of males were overweight, one third were obese and one fifth smoked, while among females, just under one third were overweight, one third obese and 15% smoked. After adjustment for age, race, baseline, disability, pain and elderly use of methotrexate, smoking and excess weight were shown to have significant independent and combined effects on the likelihood of achieving sustained remission in both men and women.

Source:

EULAR

Link to the source:

http://www.eular.org/congresspressreleases/Obesity_and_smoking_reduces_likelihood_of_treatment_success_in_early_rheumatoid_arthritis.pdf

Original title of article:

Obesity and smoking reduces likelihood of treatment success in early rheumatoid arthritis

EULAR
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