NSAID in Managing Pain during Cataract Surgery

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NSAID in Managing Pain during Cataract Surgery

A recent prospective, randomised, double-masked, placebo-controlled trial was conducted to study the role of topical Nepafenac 0.1% ophthalmic suspension in reducing pre- and post-operative pain in cataract surgery. 

The analysis was conducted on 40 patients (80 eyes) who underwent bilateral cataract surgery. The study was divided into two groups. The first group, i.e., 40 eyes received  0.1% Nepafenac along with topical anaesthesia thrice a day and once half an hour before the surgery. The second group (40 eyes) received only local anaesthesia along with placebo.

Pain evaluation was done through Verbal Pain Scale (VPS) and Visual Analogue Scale (VAS). The level of comfort was evaluated as good or bad by monitoring squeezing or movement of the eye during the surgery. 

A total of 82.5% of patients from the first group reported no or mild pain, and in the second group, only 45% of patients reported no or mild pain, rest of subjects from group second reported pain.

Nepafenac group exhibited remarkably lower mean VPS and VAS scores as compared to the placebo group. Patients from Nepafenac group also reported more surgical comfort as compared to another group.

The results consider  0.1% Nepafenac as good treatment for pain and discomfort during clear corneal phacoemulsification.


Contact Lens Anterior Eye

the source:


Original title of article:

0.1% Nepafenac reduces pain and increases patient comfort during cataract surgery


Tevfik Oğurel et al.

Therapeutic, Nepafenac, Pain, Eyes, NSAIDs, Prospective, Randomized, Double-masked, Placebo-controlled Study, Efficacy, VPS, VAS
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