A New formulation of Ibuprofen for Acute Odontogenic Pain

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A New formulation of Ibuprofen for Acute Odontogenic Pain

A recent study has revealed that a single dose of ibuprofen sodium dihydrate provided faster onset of pain relief in endodontic pain patients, reduces spontaneous and evoked pain to a great extent as compared to ibuprofen acid.

A new formulation of ibuprofen, ibuprofen sodium dihydrate, claimed to provide faster onset of analgesia. Maximum data on ibuprofen formulation are obtained through oral surgery model studies. As this model differs significantly from the endodontic pain model, a randomized, double-masked study was conducted to compare ibuprofen sodium dihydrate with conventional ibuprofen acid in endodontic pain patients.

The study involved patients a total of 41 patients suffering from moderate to severe tooth pain, diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis. All the participants were randomized and given 400 mg ibuprofen acid or an equivalent dose of 512 mg ibuprofen sodium dihydrate. The outcome measures included time to onset of 50% pain relief recorded using a stopwatch, reduction in spontaneous pain experienced on a 100 mm visual analog scale and change in mechanical allodynia, measured using a bite force transducer. The last two measures were obtained before and 60 minutes after administration of the drug.

The results revealed that median time to onset of 50% pain relief after administration of ibuprofen sodium dihydrate was significantly faster as compared to ibuprofen acid (26.5 vs. 44 minutes, P= 0.08). The great extent of reduction was obtained in spontaneous pain (50.8% vs. 33.3% p<0.05) and mechanical allodynia (15% vs. 9%, p> 0.05) by use of ibuprofen sodium dihydrate.

Therefore, it was concluded that a single dose of ibuprofen sodium dihydrate provided faster onset of pain relief in endodontic pain patients, reduces spontaneous and evoked pain to a great extent as compared to ibuprofen acid.

Source:

Journal of Endodontics

Link to the source:

http://www.jendodon.com/article/S0099-2399(16)31063-9/fulltext?rss=yes

The original title of the article:

A Randomized Clinical Trial Comparing 2 Ibuprofen Formulations in Patients with Acute Odontogenic Pain

Authors:

Taggar T, Wu D  et al.

SearchTags: 
Ibuprofen, Acute Odontogenic Pain
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