New and Future therapies for Osteoarthritis
Over the last decade, there have been several interesting advances seen for the treatment of osteoarthritis, resulting in renewed interest in this field of medicine. Recent progress in understanding the pathophysiology of OA has facilitated the development of new drugs and treatments specifically aimed at effectively retarding the disease process.
This disease is characterized by joint pain and loss of joint form and function due to articular cartilage degeneration, subchondral bone thickening and osteophyte formation.
Several factors may contribute to osteoarthritis and these usually includes obesity, ageing and trauma, but yet its mechanisms are not fully understood. Therefore, there is an ever growing need for an effective disease modifying treatment, as few advances have been made in the pharmacological intervention of disease progression. So, some of the new approaches in OA therapies have been made in the different joint tissues affected by OA pathology by targeting AC maintenance, subchondral bone, synovial membrane. Also, these targets have recently been examined.
This review throws light on the advancements in the progressing treatments and the clinical management of osteoarthritis. Although very informative, but these studies have been performed in animal models and thus more diverse clinical trials are required into human tissues and patients to truly understand the potential of these targets for therapy.