Neuropathic Pain Symptoms Delay Remission in Patients with Early Rheumatoid Arthritis

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Neuropathic Pain Symptoms Delay Remission in Patients with Early Rheumatoid Arthritis

A study published in the 'Current Rheumatology Review' showed that the presence of neuropathic pain (NeP) symptoms might affect the attainment of remission in early rheumatoid arthritis (ERA) patients. In such patients, the painDETECT questionnaire (PDQ) can be a valuable means of measuring central pain sensitization.

NeP is commonly observed in subjects with established rheumatoid arthritis (RA), and it can affect the disease remission. There is a lack of studies evaluating these effects in ERA patients.

Salaffi F et al. examined the impact of NeP on the achievement of remission in patients with ERA. The study included consecutive patients with moderately or highly active ERA (a score of >11 on the Simplified Disease Activity Index). All the patients were asked to administer the painDETECT questionnaire (PDQ), the 36-item Short Form Health Survey, and the EuroQoL-5 dimensions (EQ-5D) and their co-morbidity data were utilized to calculate their modified Rheumatic Disease Comorbidity Index (mRDCI). After six months' follow-up, the presence or otherwise of NeP in each patient was estimated, and whether or not the Boolean remission criteria were fulfilled.

A total of 115 patients with 76% being females completed the study. The PDQ scores of patients revealed that 13% had probable NeP. Twenty-five patients (21.7%) met the Boolean remission criteria at the end of the follow-up period. As per the logistic regression analysis, the baseline PDQ scores (p=0.0023) and the mRDCI (p=0.0054) were the strongest predictors of not being in Boolean remission. There were only one out of 15 patients with concomitant NeP who achieved Boolean remission.


Curr Rheumatol Rev

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Original title of the article

The effect of neuropathic pain symptoms on remission in patients with early rheumatoid arthritis


Salaffi F et al.

Exploratory, Neuropathic pain, PainDETECT questionnaire (PDQ), 36-item Short Form Health Survey, EuroQoL-5 dimensions (EQ-5D), Modified Rheumatic Disease Comorbidity Index (mRDCI), Boolean remission criteria 
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