Nanobodies may reduce pain as well as inflammation

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Nanobodies may reduce pain as well as inflammation

Inflammation is an vital part of the body's immune system, but too much of it over time can lead to problems. It is an innate reaction, it is the body's attempt to heal itself after an injury, protect itself against foreign pathogens, such as viruses and bacteria; and repair damaged tissue as soon. Without inflammation, wounds and infections could become deadly. Inflammation can also be problematic, as it also plays a role in some chronic diseases and conditions, such as allergies, asthma and atherosclerosis. Autoimmune diseases result from a failure of the body’s own defenses against disease. The immune system loses its ability to find the difference between foreign invaders and its own cells. So the body starts attacking its own organs and tissues. Scientists are trying to find a new way to controll the inflammation and mitigate the symptoms of these diseases.

In this conntext, a new study has shown that type of biological molecule called nanobodies or miniantibodies can block inflammation and reduce the pain. It is known to be 1,000 times more effective than current drugs being used and represent a next-generation strategy against inflammatory diseases. This research led by Friedrich Koch-Nolte of the University Medical Center Hamburg-Eppendorf,  Germany,  found that nanotesla or nanobodies are more effective in the management of inflammation when compared to conventional antibody or anti-inflammatory drugs. In future,  nanobodies are going to emerge as a powerful tool for the treatment of chronic pain, inflammatory bowel disease, multiple sclerosis and other inflammatory diseases. The research team also ran the mini-antibodies in a sample of human blood: nanotesla 1000 times stronger prevented the release of molecules of inflammation.

They found P2X7 channel,  in which molecules pass in and out of cells and triggers the inflammation response. Scientists tried to design drugs that selectively block P2X7, but achieved little success and reported that many drugs have been designed, don't bind only with P2X7 and also interact with other molecules in cells, produce several negative effects. Antibodies are proteins that can precisely bond with most molecules, but are ineffective in blocking the channel molecules like P2X7. While nanobodies have special properties that stand out from conventional antibodies," Koch-Nolte told LiveScience. They are fully biodegraded into non-toxic products. Koch-Nolte's group has developed nanobodies which block this channel protein P2X7 and inhibit P2X7 on immune cells. They injected mouse models of kidney inflammation and allergic contact dermatitis with this nanobody and noticed reduction in inflammation and alleviated symptoms. Therefore, it can be concluded that nanobody treatment is potent therapeutics target for inflammatory disorders.

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Fox news health

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http://www.foxnews.com/health/2016/11/28/miniantibodies-reduce-inflammat...

Original title of article:

Miniantibodies' reduce inflammation and pain

Fox news health
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