Nalbuphine hydrochloride, butorphanol tartrate and pentazocine lactate proven as effective analgesics for post-operative pain relief following abdominal hysterectomy

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Nalbuphine hydrochloride, butorphanol tartrate and pentazocine lactate proven as effective analgesics for post-operative pain relief following abdominal hysterectomy

In the last decade, our understanding of the physiology of pain and pain pathways has expanded considerably and more effective pain-relieving medications are available these days. The present study focused to distinguish the efficacy and safety of intramuscularly administered nalbuphine, butorphanol and pentazocine (opioid agonist-antagonists) for postoperative pain relief after abdominal hysterectomy.

To serve the basis of this study, 75 adult female patients, aged between 20-50 years, from the American Society of Anaesthesiologists (ASA) class 1 and 2, posted for abdominal hysterectomy under spinal anesthesia were considered. The subjects were randomly classified into 3 groups (n=25 each) and given – Group A: pentazocine lactate (30 mg, 1mL), Group B: butorphanol tartarate (2 mg, 1 ml) and Group C: nalbuphine hydrochloride (10 mg, 1 mL) when postoperative pain intensity reached ≥4 mm on the Visual analogue scale (VAS). For 24 hours postoperatively, the onset, duration, time to peak effect and adverse events were recorded at regular intervals.

The mean time to onset of anesthesia was appreciably faster (P<0.05 each) in the nalbuphine (10.2±2.2 minutes) and butorphanol (11.3±2 minutes) groups when compared to the pentazocine group (14±2.7 minutes). The duration of  analgesic action was notably longer (P<0.05 each) in the nalbuphine (236.4±75.1 minutes) and butorphanol (202±59.2 minutes) groups when compared to the pentazocine group (177.4±55.3 minutes). As for the respiratory and cardiovascular parameters, no significant differences were recorded between the groups. The pentazocine group (36%) had  significantly higher nausea and vomiting when compared to butorphanol (20%) and nalbuphine (8%) groups (P<0.05 each).

Hence, it was found that intramuscular nalbuphine and butorphanol provides an effective analgesia with rapid onset and longer duration of action, with lower incidence of nausea and vomiting as compared to pentazocine. Particularly, nalbuphine can be a satisfactory agent to provide post-operative pain relief in gynecologic lower abdominal surgery.

Source:

International Journal of Basic & Clinical Pharmacology

Link to the source:

http://http://www.scopemed.org/fulltextpdf.php?mno=245893

Original title of article:

A prospective, randomized, double blind, comparative study of intramuscular nalbuphine hydrochloride, butorphanol tartrate and pentazocine lactate for post-operative pain relief following abdominal hysterectomy

Authors

 Praveen P. V. V. S. B. et al.

International Journal of Basic & Clinical Pharmacology

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