Muscle Injections with Lidocaine Improve Resting Fatigue and Pain in Patients with Chronic Fatigue Syndrome

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Muscle Injections with Lidocaine Improve Resting Fatigue and Pain in Patients with Chronic Fatigue Syndrome
Key Take-Away: 

Chronic fatigue syndrome (CFS) is a disabling disorder marked by unexplained chronic fatigue, exertion intolerance, and sleep and cognitive abnormalities. A study showed a reduction in fatigue levels after administration of lidocaine injections

Patients with chronic fatigue syndrome (CFS) complain of long-lasting fatigue and pain which are not relieved by rest and worsened by physical exertion.

ABSTRACT: 
Background: 

Patients with chronic fatigue syndrome (CFS) complain of long-lasting fatigue and pain which are not relieved by rest and worsened by physical exertion.

Previous research has implicated metaboreceptors of muscles to play an important role in chronic fatigue and pain. Therefore, the present study hypothesized that blocking impulse input from deep tissues with intramuscular lidocaine injections would improve not only the pain but also fatigue of CFS patients.

Methods: 

In a double-blind, placebo-controlled study, 58 CFS patients received 20 mL of 1% lidocaine (200 mg) or normal saline once in both trapezius and gluteal muscles.

Study outcome measures included the assessment of clinical fatigue and pain, depression, and anxiety. Also, mechanical and heat hyperalgesia was assessed, and serum levels of lidocaine were obtained after the injections.

Results: 

Fatigue ratings of CFS patients decreased significantly after lidocaine compared to saline injections (p=0.03). In contrast, muscle injections reduced pain, depression, and anxiety (p<0.001), but these changes were not statistically different between lidocaine and saline (p>0.05).

Lidocaine injections increased mechanical pain thresholds of CFS patients (p=0.04) but did not affect their heat hyperalgesia. Importantly, mood changes or lidocaine serum levels did not significantly predict fatigue reductions.

Conclusion: 

These results demonstrate that lidocaine injections reduce clinical fatigue of CFS patients significantly more than placebo, suggesting an important role of peripheral tissues in chronic fatigue. Future investigations are warrented to evaluate the clinical benefits of such interventions.

 

Source:

Dove press

Link to the source:

https://www.dovepress.com/muscle-injections-with-lidocaine-improve-resting-fatigue-and-pain-in-p-peer-reviewed-fulltext-article-JPR

The original title of the article:

Muscle injections with lidocaine improve resting fatigue and pain in patients with chronic fatigue syndrome

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