Multimorbidity in patients with chronic migraine and medication overuse headache

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Multimorbidity in patients with chronic migraine and medication overuse headache
Key Take-Away: 

A chronic migraine is linked with a significant number of comorbidities. The study results affirm that the effect and rate of this multimorbidity can be a risk factor for migraine chronification and medication overuse headache also hampers its management.


One of the major risk factors for a chronic migraine (CM) management is the multimorbidity as the patients with CM represent a significant number of comorbidities, especially cardiovascular and psychiatric. The study aims to discuss the effect and the frequency of multimorbidity in CM and medication overuse headache (MOH) patients.



Among the CM patients that were visiting a structured withdrawal for coexisting MOH, the analysis determined multimorbidity along with CM-MOH. A comparison of clinical and demographic variables, functional disability and quality of life were done between the groups. Researchers also evaluated whether patients with multimorbidity had a greater possibility to visit the emergency room, need additional withdrawal treatments or relapse into CM by 12 months.



A total of 194 patients were registered for analysis. Out of these patients, 61% showed only one comorbidity and 32% presented with multimorbidity. The old patients or patients with greater disability, lower QoL, higher headache rate and lower employment rate/education showed multimorbidity. After screening for gender, headache frequency, years of education, and age, patients found have a higher incidence of barbiturates/opioids usage, another withdrawal, attend ER and relapse into CM by 12 months after discharge.



Understanding multimorbidity in CM-MOH patients is essential to improve the management of these complicated patients, who are at risk of polypharmacy and raised health care utilization.


Acta Neurol Scand

Link to the source:

Original title of article:

Multimorbidity in patients with chronic migraine and medication overuse headache.


Domenico D'Amico et al.

Exploratory, Migraine, Head, Chronic
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