Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial

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SCIENCE
Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial
Key Take-Away: 

The culmination of this article proved that morphine lead to a significant pain relief in the first 20 minutes of its administration as compared to indomethacin. Although the mean pain score between the two was not impressively different.

Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain.

ABSTRACT: 
Background: 

Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain.

Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic.

 

Methods: 

One hundred and fifty-eight patients were divided into two groups (n=79) and received either 10 mg morphine or 100 mg indomethacin suppositories.

The severity of pain was measured using verbal numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the administration of analgesics. Drug side effects as well as patients’ vital signs were also recorded. 

Results: 

The mean decrease in the pain score during the first 20 minutes was significantly higher among those who received morphine suppository.

However, no significant difference was observed between the two groups regarding the mean decrease in pain score during the first 40, 60, and 90 minutes after the admission. Prevalence of drug side effects or changes in the vital signs was not significantly different between the two groups. 

 

Conclusion: 

Morphine suppositories seem to be more efficient in achieving rapid pain relief comparing to indomethacin.

Pain Research and Treatment 2016
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