Methotrexate as an Effective and Safe Choice for the Treatment of Rheumatoid Arthritis

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Methotrexate as an Effective and Safe Choice for the Treatment of Rheumatoid Arthritis
Key Take-Away: 

Rheumatoid arthritis (RA) is an autoimmune disorder that significantly affects joints. Methotrexate, an immunosuppressive (IS) drug used as the first line of treatment against RA is regarded as the safe and potent treatment modality for RA.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting joints. For controlling the disease activity, various therapeutic modalities are used

ABSTRACT: 
Background: 

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting joints.

For controlling the disease activity, various therapeutic modalities are used. Each of them has advantages and limitations. This study analyzes effectiveness and toxicity of methotrexate (MTX) on liver and lipid functions in RA patients.

Methods: 

This study included patients with RA who were on MTX therapy and had long-term follow-up.

The control and patient samples were used for the analysis of lipid parameters, inflammatory markers as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), essential mineral accumulation, and liver and kidney function test.

Results: 

Hemoglobin was reduced in RA patients; however, ESR, CRP, and pain on the visual analog scale were significantly higher as compared to controls.

Their alanine aminotransferase, aspartate aminotransferase, and uric acid were within normal ranges. Serum magnesium was significantly reduced in RA patients. They showed higher values for zinc, phosphorous, and copper. They had borderline dyslipidemia.

Conclusion: 

MTX was found to be safe and effective for the treatment of RA. The liver function test of RA patients was normal; however, disturbances in mineral accumulation, suggesting the requirement of mineral evaluation and supplementation especially of magnesium was reported. The treatment was beneficial in reducing the inflammation and the disease activity, and the risk of cardiovascular disease. The study supports the use of MTX as a preferred choice of treatment in RA patients.

 

Source:

Current Orthopaedic Practice

Link to the source:

http://journals.lww.com/corthopaedicpractice/Abstract/2017/07000/Methotrexate_as_effective_and_safe_choice_for_the.18.aspx

The original title of the article:

Methotrexate as effective and safe choice for the treatment of rheumatoid arthritis

Authors:

Kumar et al.

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