A longitudinal study shows ultrasound sensitivity to changes in gout

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A longitudinal study shows ultrasound sensitivity to changes in gout

Ultrasound (US) findings in gout patients showed sensitivity to change and concurrent validation with a uric acid reduction after urate-lowering therapy (ULT) in gout patients. Recently, a study was performed to evaluate the effect of ULT on gout US lesions and review sensitivity of US to changes in gout patients.

The study included a total of 23 consecutive patients (96% men; mean age 59 ± 11 years). DCS and US tophi were diagnosed in 73.9% and 91.3% of patients at baseline. Patients with chronic and symptomatic gout were confirmed by crystal identification and were enrolled in the study. Clinical and US evaluations were performed at baseline and after 6, 12 and 24 months of ULT.

The presence of double contour sign (DCS) and US-detectable tophi were assessed in the first metatarsophalangeal, the knees and patellar tendons. Calculation of the mean and standard deviation (mean±SD) was done for each parameter, and the correlation between the clinical and US parameters was assessed by calculating Pearson’s correlation coefficient. The smallest detectable differences were estimated to analyze sensitivity to change in the US examinations. A follow-up assessment revealed a significant parallel improvement in the serum urate, clinical parameters, and US lesions.

A significant correlation between DCS and clinical parameters was observed (r=0.49, p=0.038). Ultrasound findings in gout patients showed sensitivity to change and concurrent validation with uric acid reduction after ULT in gout patients. Therefore, US can be regarded as a useful tool for gout tophus burden monitoring.

Source:

Clinical and Experimental Rheumatology (Journal with Online Submission)

Link to the source:

http://www.cinexprhleumatol.org/abstract.asp?a=11214

Original title of article:

Ultrasound sensitivity to changes in gout: a longitudinal study after two years of treatment

Authors:

D. Peiteado et al.

SearchTags: 
Ultrasound sensitivity, Gout, Urate-lowering therapy
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