Liposomal Bupivacaine and Periarticular Injection vs Single-Shot Intra-articular Injection in Total Knee Arthroplasty
Knee arthroplasty or knee replacement is a common concern nowadays. Intraoperative injections can help to reduce the early postoperative pain in total knee arthroplasty. Some proposals have been made that liposomal bupivacaine would not be superior to more common and cheaper injections.
A single blinded randomized study was conducted, which was completed with 207 consecutive patients. Periarticular liposomal bupivacaine injection, periarticular injection of bupivacaine/morphine or intra-articular injection of bupivacaine/morphine was given to the patients for the treatment and results were evaluated at the conclusion of procedure. Post operative visual analog pain scores and narcotic consumption were recorded and analyzed at the completion of process.
However, there were no significant difference in postoperative visual analog pain scores or narcotic consumption among all the three study groups.
Intra-articular injection of bupivacaine and morphine was reported as effective for the post operative pain control in total knee arthroplasty as periarticular bupivacaine/morphine injection and liposomal bupivacaine. No significant differences were reported in postoperative visual analog pain scores or narcotic consumption among the 3 study groups, whereas the use of liposomal bupivacaine in total knee arthroplasty is costly and not justified.