Ketamine can be used to treat refractory headache

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Ketamine can be used to treat refractory headache

Ketamine has been in clinical use for over 30 years now. This drug has been studied and tested on patients with various painful conditions due to its profound analgesic properties. Recent evidence have shown that ketamine might be a therapeutic option for chronic migraine (CM) or new daily persistent headache (NDPH) in those who require aggressive outpatient and inpatient treatment.

A retrospective review of 77 patients who underwent administration of intravenous, subanesthetic ketaminefor chronic migraine or new daily persistent headache was conducted by investigators at Thomas Jefferson University. The researchers found that the mean headache pain rating using a 0-10 pain scale was an average of 7.1 at admission and 3.8 on discharge. Moreover, the majority (55/77, 71.4%) of patients were classified as acute responders which was defined as at least 2-point improvement in headache pain at the time of discharge. Even more encouraging, they found that some (15/77, 27.3%) acute responders maintained this benefit at their follow-up office visit. The mean length of infusion in this subset of patients was 4.8 days and ketamine (intra venous) was found to be well tolerated. These results strenghtens previous clinical studies suggesting that ketamine can be used to treat chronic migraine. Further, more robust studies are required to confirm findings in a less refractory patient population.

Source:

Headache–the Journal of Head and Face Pain

Link to the source:

http://onlinelibrary.wiley.com/doi/10.1111/head.13013/abstract;jsessioni...

Original title of article:

Ketamine Infusions for Treatment Refractory Headache.

Authors:

Jared L. Pomeroy, Michael J. Marmura, Stephanie J. Nahas, Eugene R. Viscusi

Headache–the Journal of Head and Face Pain
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