Inflammation on Spinal MRI Negatively Associates with the Trabecular Bone Score in Ankylosing Spondylitis Patients

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Inflammation on Spinal MRI Negatively Associates with the Trabecular Bone Score in Ankylosing Spondylitis Patients

According to a recent study published in Modern Rheumatology Journal, the trabecular bone score of patients with ankylosing spondylitis shows a negative association with the inflammation on spinal magnetic resonance imaging (MRI). These outcomes recommend that osteoporosis can be successfully prevented by controlling the active bone inflammation among AS patients.

Joon-Yung Jung et al. included ninety-seven ankylosing spondylitis patients. To determine bone mineral density (BMD) and trabecular bone score (TBS), all the included patients went through dual energy x-ray absorptiometry and MRI of the lumbar spine. The bone marrow edema (BME ) observed on MRI was marked as an inflammatory lesion. The occurrence, intensity, and depth (>1 cm) of BME on MRI were calculated for the 1st–4th lumbar spine segments. During MRI, the spinal structural damage score and inflammatory markers were also determined. The relationship between TBS and inflammatory activity score at the time of MRI were also assessed.

Fifty-two patients out of the total 97 patients had BME on spinal MRI. The mean TBS values for patients without and with BME were 1.43±0.11 and 1.38±0.1, respectively. A negative association was observed between the total inflammatory activity scores on spinal MRI and TBS. However, no negative association was found with BMD. Patients with TBS value depicting a high risk of fracture had more deep BME (>1 cm) (p = .048) on MRI. A significant reduction in TBS was observed with an increase in the severity of inflammation on MRI after adjusting for age, symptom duration, and lumbar spinal structural damage.

Source

Modern Rheumatology

Link to the source:

https://www.tandfonline.com/doi/abs/10.1080/14397595.2018.1510877

Original title of the article:

Inflammation on spinal magnetic resonance imaging is associated with poor bone quality in patients with ankylosing spondylitis

Authors:

Joon-Yong Jung et al.

SearchTags: 
Exploratory, Osteoporosis, Bones, MRI
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