Importance of Olive and Grape Seed Extract in Combating Post-Traumatic Osteoarthritis Damage and its Anti IL-1β Activity

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Importance of Olive and Grape Seed Extract in Combating Post-Traumatic Osteoarthritis Damage and its Anti IL-1β Activity

Osteoarthritis is a chronic inflammtory condition causing progressive damage to the cartilages of the bones resulting in pain and stiffness in the joints of the body, especially the knee, elbow, neck and the hip joint. Although osteoarthritis can occur in anyone, it is more common in women and the elderly population. The role of polyphenols in the prevention of age-related disorders has been studied extensively.

The current study mentioned here was performed to assess the preventive anti-osteoathritic effects of an  olive and grape seed extract standardized as per the hydroxytyrosol (HT) and procyanidins (PCy) content.Assessment of HT/PCy mix was performed to confirm its (i) in vitro anti-inflammatory and chondroprotective actions, (ii) its anti-osteoarthritis effects in two post-traumatic animal models and (iii) its ability to maintain its bioactivity after oral administration. Anti-inflammatory and chondroprotective actions of HT/PCy were tested on primary cultured rabbit chondrocytes invigorated by interleukin-1 beta (IL-1β).

The results of this study revealed that HT/PCy exerts anti-inflammatory and chondroprotective actions in vitro. The preventive effect of HT/PCy association was analysed in two animal models of post-traumatic OA in mice and rabbits. In the two complementary mice and rabbit models, the diet supplementation with HT/PCy significantly lowered the severity of post-traumatic osteoarthritis. After gavage with HT/PCy in rabbits, the bioavailability and bioactivity was assessed. Regular metabolites from HT/PCy extract were found in sera from rabbits after oral intake. Ultimately, sera from rabbits force-fed with HT/PCy conserved anti-IL-1β effect, advocating the bioactivity of this extract.

Therefore, it can be concluded that the HT/PCy extract may be of clinical significance for the preventive treatment of osteoarthritis. 

Scientific Reports
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