Impact of neuropathic pain associated with breast cancer treatment on sleep quality

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Impact of neuropathic pain associated with breast cancer treatment on sleep quality
Key Take-Away: 

Breast cancer treatment often leads to neuropathic pain which results in deterioration of the sleep quality; however, evidences for this finding are not fully discovered. The study presented here is based on the understanding of sleep impairment associated with neuropathic pain occurring in the first year after the diagnosis of breast cancer.

Data regarding the impact of breast cancer treatment-related neuropathic pain (NP) on sleep quality are scarce.

ABSTRACT: 
Background: 

Data regarding the impact of breast cancer treatment-related neuropathic pain (NP) on sleep quality are scarce.

Therefore, the study aimed to assess the impact of breast cancer treatment-related NP on patients' sleep quality, during the first year after the diagnosis.

Methods: 

A total of 501 breast cancer patients were followed prospectively. Incident NP was identified through systematic evaluations after the treatments and one year after the enrollment.

The severity of NP was quantified using the Brief Pain Inventory severity sub scale and sleep quality was evaluated through the Pittsburgh Sleep Quality Index (PSQI), at baseline and after one year. Adjusted regression coefficients (β) and 95% confidence intervals (95%CI) were used to quantify the relation between NP and the variation in the PSQI z-scores.

Results: 

The occurrence of NP was associated with a deterioration in sleep quality during the first year of follow-up, more pronounced among those with good sleep quality (PSQI≤5) than those with poor sleep quality at baseline (PSQI>5) (β = 0.44, 95%CI: 0.11 to 0.77 versus β = 0.33, 95%CI: 0.08 to 0.59).

These differences were accentuated when only the cases of NP with greater severity were considered (β = 0.86, 95%CI: 0.37 to 1.35 versus β = 0.31, 95%CI: −0.08 to 0.64). Within the PSQI components, daytime dysfunction and sleep duration were the most impaired by NP.

Conclusion: 

The findings highlight the importance of the promotion of sleep hygiene among breast cancer patients diagnosed with NP, especially among those with good sleep quality before the treatment.

Source:

The Breast

Link to the source:

http://www.thebreastonline.com/article/S0960-9776(17)30420-4/fulltext?rss=yes

The original title of the article:

Neuropathic pain after breast cancer treatment and its impact on sleep quality one year after cancer diagnosis

Authors:

Filipa Fontes et al.

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