Higher prevalence of upper gastrointestinal bleeding risk components among osteoarthritis patients

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Higher prevalence of upper gastrointestinal bleeding risk components among osteoarthritis patients

Upper gastrointestinal bleeding (UGIB) pose to be a high-risk state with high morbidity and mortality notwithstanding advances in medical science. The prevalence of possible risk factors for UGIB and Osteoarthritis (OA) patients of specific age-group  trending among the general population had been investigated in the study by Kim S, et al.

The National Health Insurance Service provided the data that comprised of claimed data and outcomes of the national health check-up program. The plausible UGIB risk components were comorbid conditions (peptic ulcer, diabetes, liver disease, chronic renal failure and gastroesophageal reflux disease), concomitant drugs (aspirin, clopidogrel, cilostazol, non-steroidal anti-inflammatory drugs, steroid, anticoagulants and SSRI), personal habits (smoking and alcohol consumption). The prevalence of infection in the data was randomly attributed considering the age-specific prevalence of Helicobacter pylori (H. pylori) infection in Korea. The frequency of different UGIB risk factors and the age-group specific trend of the frequency were revealed. Comparison of frequency between OA patients and others was done.

Overall, 801926 participants (93855 OA patients) aged 20 and above were included in the study. With the increasing age, the frequency of individual and concurrent multiple risk factors also became higher. In OA patients, the frequency of each comorbid condition and the concomitant drug was higher. At least one or more risk factors of UGIB were observed in 68.50% of OA patients and 35.02% of the overall population. In younger age groups, the frequency of individual and concurrent multiple risk factors was also noticed. Also, when personal habits (smoking and alcohol consumption) and H. Pylori infection were considered, the frequency of concurrent multiple risk factors escalated greatly even in younger age groups.

The prevalence of UGIB risk factors was reported to be higher in the elderly population and significant in the younger population. While the higher UGIB risk was observed in the patient with OA than those without OA. The physicians should consider individualized risk assessment regardless of age when prescribing drugs or performing procedures that may increase the risk of UGIB. Appropriate measures need to be taken to lessen the modifiable risk factors likes H. Pylori eradication or lifestyle counseling.

Source:

World Journal of Gastroenterology

Link to the source:

http://www.wjgnet.com/1007-9327/full/v22/i48/10643.htm

The original title of the article:

Prevalence of upper gastrointestinal bleeding risk factors among the general population and osteoarthritis patients

Authors

Sang Kim et al.

SearchTags: 
Exploratory, Osteoarthritis, Joints
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