Handheld Extrusion Device found Useful for the Biofabrication of Human Cartilage

Primary tabs

NEWS
Handheld Extrusion Device found Useful for the Biofabrication of Human Cartilage

A handheld extrusion device represents a novel treatment approach for customizing cartilage repair in patients with cartilage injuries and OA, confirms a recent study published in the "Biofabrication Journal". Cartilage injuries are painful, cause functional disability and may also result in osteoarthritis (OA).

3D printing is a great option to deliver bioscaffolds competent in restoring the defective cartilage tissues. A team of scientists has produced a handheld device, that permits in situ additive manufacturing during surgery. This device has the ability to project in a core/shell manner and thus can maintain cell viability during the biofabrication process. The handheld device is presently the only biofabrication tool examined as a surgical device in the animal (sheep) model using homologous stem cells. Carmine Onofrillo and colleagues took an important step for the growth of a clinically relevant protocol and conducted the present study to confirm if the handheld extrusion device can successfully be used for the biofabrication of human cartilage.

The human adipose-derived mesenchymal stem cells (hADSCs), collected from the infrapatellar fat pad of donor patients suffering from OA were utilized for the study. The bioscaffolds formed of hADSCs loaded in gelatin methacrylate, hyaluronic acid methacrylate and cultured in the presence of chondrogenic stimuli were generated. The comprehensive characterization analysis revealed that the handheld device can regenerate human hyaline-like cartilage and thus represents a promising novel intervention for cartilage repair in patients with cartilage injuries and OA.

Source

Biofabrication

Link to the source:

http://iopscience.iop.org/article/10.1088/1758-5090/aad8d9

Original title of the article:

Biofabrication of human articular cartilage: a path towards the development of a clinical treatment

Authors:

Carmine Onofrillo et al.

SearchTags: 
Therapeutic, Osteoarthritis, Joints, Efficacy
Log in or register to post comments