Five percent lidocaine medicated plaster is safe and effective in elderly patients with postherpetic neuralgia

Primary tabs

NEWS
Five percent lidocaine medicated plaster is safe and effective in elderly patients with postherpetic neuralgia

The recent study was implemented to find out the short- and long-term effectiveness and safety of the 5% lidocaine medicated plaster in postherpetic neuralgia (PHN) in elderly patients (≥70 years of age).

After stratification according to the age (<70 years and ≥70 years), the data from three European clinical trials were compared. The length of study phase was 4 weeks for study 1, 8 weeks for study 2, and up to 12 months for study 3. Pain intensity, pain relief, allodynia severity, Clinical Global Impression of Change, and Global Patient Impression of Change were the effectiveness outcome measures. The adverse event documentation was used to estimate the safety.

The mean average pain intensity ameliorated in the elderly patients was reported to be −2.1 (SD 2.1) vs. −2.5 (SD 2.0) for <70 year-old patients after 4 weeks, by −1.4 (SD 1.8) vs. −1.7 (SD 1.3) after 8 weeks, and by −1.5 (SD 1.9) vs. −2.7 (SD 2.2) after 12 months. Most patients presented with allodynia (>85% of elderly, >78% of younger patients) were delineated by >51% as painful or extremely painful. During all the three trials, allodynia severity was markedly reduced in both groups and drug-related adverse events were observed in <20% of elderly and <15% of <70 year-old patients who were mainly skin related.

It culminated that 5% lidocaine medicated plaster provided pain relief and marked reductions in allodynia severity in elderly PHN patients with an outstanding safety profile. This was observed under the short and long-term treatment, bracing the addition of the plaster to the treatment armamentarium for this age group.

Source:

Current Medical research and opinion

Link to the source:

http://www.tandfonline.com/doi/abs/10.1080/03007995.2016.1277990

Original title of the article:

Treatment of postherpetic neuralgia with 5% lidocaine medicated plaster in elderly patients – subgroup analyses from three European clinical trials

Authors

Navjot Chaudhary et al.

SearchTags: 
Therapeutic, Lidocaine, Postherpetic neuralgia (PHN), Pain, Class-1b antiarrhythmic drug, Subgroup analyses, Safety, Efficacy, Pain intensity, Pain relief, Allodynia severity, Clinical Global Impression of Change, Global Patient Impression of Change, Skin related, Topical
Log in or register to post comments